Oxaflozane

Oxaflozane (INN) is a chemical compound and antidepressant that was introduced in France by Lafon Laboratories in 1982 for the treatment of depression. It is a serotonin antagonist and reuptake inhibitor (SARI) and acts as a receptor antagonist at several serotonin receptors and as a serotonin reuptake inhibitor.

Chemistry

Oxaflozane is a tricyclic compound, specifically a dibenzoxazepine, and possesses three rings fused together with a side chain attached at one of the ring junctions. It is a member of the diphenylbutylpiperidine class of antipsychotics.

Pharmacology

Oxaflozane is a potent and selective antagonist of the 5-HT2A receptor, and this action is thought to be involved in its antidepressant effects. It also has weak inhibitory effects on the reuptake of serotonin.

Clinical Use

Oxaflozane was used in France for the treatment of depression until it was discontinued in 2002 due to poor sales. It was never approved for use in the United States or any other country.

Side Effects

Common side effects of oxaflozane include dizziness, dry mouth, insomnia, and nausea. Rare side effects include agitation, anxiety, and hallucinations.

See Also

• List of antidepressants
• List of serotonin antagonists