P-Toluic acid
P-Toluic acid, also known as 4-methylbenzoic acid, is an organic compound that belongs to the family of carboxylic acids. It is a derivative of toluene through the substitution of a methyl group at the para position relative to the carboxyl group. P-Toluic acid is one of the three isomeric forms of methylbenzoic acid, the others being o-toluic acid (ortho) and m-toluic acid (meta). This compound is of interest in both academic research and various industrial applications due to its chemical properties and its role as a building block in organic synthesis.
Structure and Properties[edit | edit source]
P-Toluic acid (C8H8O2) features a benzene ring with a carboxyl group (-COOH) and a methyl group (-CH3) attached at the para positions. This structural arrangement imparts certain physical and chemical properties to the compound, including a melting point of 178-181 °C and a boiling point of 274 °C. It is slightly soluble in water but more soluble in organic solvents such as ethanol, diethyl ether, and benzene.
Synthesis[edit | edit source]
P-Toluic acid can be synthesized through several methods. One common approach involves the oxidation of p-xylene or 4-methyltoluene, using oxidizing agents such as potassium permanganate (KMnO4) or chromic acid (H2CrO4). Another method is the Friedel-Crafts acylation of benzene with acetyl chloride in the presence of an aluminum chloride (AlCl3) catalyst, followed by the methyl group's para substitution.
Applications[edit | edit source]
P-Toluic acid finds applications in various fields, primarily in the synthesis of other chemicals. It serves as a precursor for the manufacture of esters, which are used in perfumes and flavorings. It is also employed in the production of plasticizers, dyes, and pharmaceuticals, where it can be a starting material for the synthesis of more complex molecules. In academic research, p-toluic acid is often used in studies related to organic synthesis and reaction mechanisms.
Safety and Handling[edit | edit source]
Like many chemical compounds, p-toluic acid requires careful handling. It can cause irritation to the skin, eyes, and respiratory system upon exposure. Appropriate safety measures, including the use of personal protective equipment (PPE) such as gloves and goggles, are recommended when handling this compound. It should be stored in a cool, dry place, away from incompatible materials such as strong oxidizing agents.
Environmental Impact[edit | edit source]
The environmental impact of p-toluic acid is generally considered low, as it does not persist in the environment due to its biodegradability. However, like all chemicals, it should be disposed of responsibly to minimize any potential harm to the environment.
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD