Peroxisome proliferator-activated receptor gamma
(Redirected from PPARG)
Peroxisome proliferator-activated receptor gamma (PPAR-γ or PPARG), also known as the glitazone receptor, is a type of nuclear receptor that is of interest for its role in biology and medicine. PPARG regulates fatty acid storage and glucose metabolism. The genes activated by PPARG stimulate lipid uptake and adipogenesis by fat cells.
Function[edit | edit source]
PPARG binds peroxisome proliferators and controls the size and number of peroxisomes produced within cells. PPARG is a regulator of adipocyte differentiation, and it also has anti-inflammatory effects and inhibits the vasoconstriction of vascular smooth muscle cells.
Clinical significance[edit | edit source]
PPARG has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis, and cancer. PPARG agonists have been used in the treatment of hyperlipidaemia and hyperglycemia.
Ligands[edit | edit source]
Several different kinds of ligands can bind to PPARG, including synthetic ligands, naturally occurring fatty acids, and prostaglandins.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- PPARG at the US National Library of Medicine Medical Subject Headings (MeSH)
| Peroxisome proliferator-activated receptor gamma Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
