Pratosartan
Pratosartan is a pharmaceutical drug that belongs to the class of angiotensin II receptor antagonists, commonly known as ARBs. It is primarily used in the management of hypertension (high blood pressure) and may also be prescribed for other cardiovascular conditions.
Mechanism of Action[edit | edit source]
Pratosartan works by selectively blocking the binding of angiotensin II to the angiotensin II receptor type 1 (AT1 receptor) in various tissues, including vascular smooth muscle and the adrenal gland. This inhibition prevents the vasoconstrictor and aldosterone-secreting effects of angiotensin II, leading to vasodilation and a reduction in blood pressure.
Pharmacokinetics[edit | edit source]
Pratosartan is administered orally and is absorbed through the gastrointestinal tract. It undergoes hepatic metabolism, primarily by the cytochrome P450 enzyme system. The drug is excreted mainly through the kidneys, and its elimination half-life allows for once-daily dosing.
Clinical Uses[edit | edit source]
Pratosartan is indicated for the treatment of:
Adverse Effects[edit | edit source]
Common side effects of Pratosartan include:
Serious adverse effects may include:
Contraindications[edit | edit source]
Pratosartan is contraindicated in patients with:
- Hypersensitivity to the drug or its components
- Pregnancy, due to the risk of fetal toxicity
Drug Interactions[edit | edit source]
Pratosartan may interact with:
Research and Development[edit | edit source]
Pratosartan is currently under investigation for its potential benefits in other conditions such as diabetic nephropathy and left ventricular hypertrophy.
Also see[edit | edit source]
References[edit | edit source]
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