Ripisartan

Ripisartan is a pharmaceutical compound that belongs to the class of angiotensin II receptor antagonists, commonly known as ARBs. These medications are primarily used in the management of hypertension (high blood pressure) and certain types of heart failure.

Mechanism of Action

Ripisartan works by selectively blocking the binding of angiotensin II to the angiotensin II receptor type 1 (AT1 receptor) in various tissues, including vascular smooth muscle and the adrenal gland. This inhibition prevents the vasoconstrictive and aldosterone-secreting effects of angiotensin II, leading to vasodilation and a reduction in blood pressure.

Pharmacokinetics

Ripisartan is administered orally and is absorbed through the gastrointestinal tract. The bioavailability of ripisartan can be affected by food intake, and it is recommended to be taken consistently with respect to meals. The drug is metabolized in the liver, primarily by the cytochrome P450 enzyme system, and is excreted via the kidneys.

Clinical Uses

Ripisartan is indicated for the treatment of:

• Hypertension: To lower blood pressure and reduce the risk of cardiovascular events such as myocardial infarction and stroke.
• Heart failure: To improve symptoms and reduce mortality in patients with heart failure.

Side Effects

Common side effects of ripisartan include:

• Dizziness
• Headache
• Fatigue
• Hyperkalemia (elevated potassium levels)

Serious side effects may include:

• Angioedema
• Renal impairment

Contraindications

Ripisartan is contraindicated in patients with:

• Hypersensitivity to ripisartan or any component of the formulation
• Pregnancy: Due to the risk of fetal toxicity

Drug Interactions

Ripisartan may interact with other medications, including:

• Nonsteroidal anti-inflammatory drugs (NSAIDs)
• Potassium-sparing diuretics
• Lithium

Also see

• Angiotensin II receptor antagonist
• Hypertension
• Heart failure
• Renin-angiotensin system

References

Template:Antihypertensive drugs