Spinorphin

Spinorphin is a hexapeptide that has been identified as an endogenous inhibitor of enkephalin-degrading enzymes. It was first isolated from the bovine neurohypophysis, and has been shown to have potent analgesic effects.

Structure and Function

Spinorphin is composed of six amino acids, with the sequence LVVYPWT. This sequence is also found in the protein hemoglobin subunit beta. The peptide has been shown to inhibit the degradation of enkephalins, which are endogenous opioid peptides that play a role in pain perception and mood regulation.

Spinorphin's analgesic effects are thought to be due to its ability to enhance the activity of enkephalins. By inhibiting the enzymes that degrade these peptides, spinorphin increases the amount of enkephalins available to bind to opioid receptors, thereby enhancing their analgesic effect.

Clinical Significance

Due to its potent analgesic effects, spinorphin has potential for use in the treatment of pain. However, further research is needed to fully understand its mechanism of action and potential side effects.

See Also

• Enkephalin
• Opioid peptide
• Analgesic

References

Spinorphin Resources
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