Usual interstitial pneumonia
Usual Interstitial Pneumonia[edit | edit source]
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Usual interstitial pneumonia (UIP) is a specific form of lung disease characterized by progressive scarring of both lungs. It is the most common form of idiopathic pulmonary fibrosis (IPF), a type of interstitial lung disease.
Clinical Features[edit | edit source]
Patients with UIP typically present with dyspnea (shortness of breath) and a persistent dry cough. The disease is more common in older adults, particularly those over the age of 50. Physical examination may reveal clubbing of the fingers and crackles on lung auscultation.
Pathology[edit | edit source]
The hallmark of UIP is the presence of patchy interstitial fibrosis, which is most pronounced in the subpleural and basal regions of the lungs. Histologically, UIP is characterized by the presence of fibroblastic foci, honeycomb change, and temporal heterogeneity of fibrosis.
Diagnosis[edit | edit source]
Diagnosis of UIP is typically made through a combination of clinical, radiological, and pathological findings. High-resolution computed tomography (HRCT) scans of the chest are crucial for diagnosis, often showing a pattern of reticular opacities, traction bronchiectasis, and honeycombing. A lung biopsy may be performed to confirm the diagnosis.
Treatment[edit | edit source]
There is no cure for UIP, and treatment is primarily supportive. Antifibrotic medications such as pirfenidone and nintedanib may slow disease progression. Lung transplantation is an option for eligible patients with advanced disease.
Prognosis[edit | edit source]
The prognosis for patients with UIP is generally poor, with a median survival of 3 to 5 years after diagnosis. The disease course is variable, with some patients experiencing rapid progression and others having a more indolent course.
Related Pages[edit | edit source]
CT scan showing usual interstitial pneumonia
CT scan of usual interstitial pneumonia
Lung biopsy showing usual interstitial pneumonia
Honeycomb change in usual interstitial pneumonia
Fibroblast focus in usual interstitial pneumonia
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