Uterine clear-cell carcinoma

Uterine clear-cell carcinoma (UCCC) is a rare subtype of endometrial cancer, which is a type of cancer that begins in the uterus. It is characterized by the presence of clear cells, which are a type of cell that can be seen under a microscope. UCCC is considered to be a high-grade tumor, meaning it is likely to grow and spread more quickly than other types of endometrial cancer.

Epidemiology

UCCC is a rare form of endometrial cancer, accounting for less than 5% of all cases. It is more common in postmenopausal women, although it can occur at any age. The exact incidence of UCCC is unknown, as it is often grouped together with other types of endometrial cancer in epidemiological studies.

Pathogenesis

The exact cause of UCCC is unknown. However, it is thought to develop from the endometrial lining of the uterus, similar to other types of endometrial cancer. Some studies suggest that certain genetic mutations may play a role in the development of UCCC, although more research is needed in this area.

Clinical Presentation

Women with UCCC may experience a variety of symptoms, including abnormal vaginal bleeding, pelvic pain, and a palpable mass in the pelvic area. However, many women with UCCC do not have any symptoms until the disease has advanced.

Diagnosis

The diagnosis of UCCC is typically made through a combination of physical examination, imaging studies, and biopsy. The definitive diagnosis is made by examining tissue from the tumor under a microscope.

Treatment

The treatment of UCCC typically involves surgery to remove the uterus, fallopian tubes, and ovaries. This is often followed by radiation therapy or chemotherapy to kill any remaining cancer cells. The choice of treatment depends on the stage of the disease, the patient's overall health, and the patient's personal preferences.

Prognosis

The prognosis for women with UCCC is generally poor, due to the aggressive nature of the disease. However, early detection and treatment can improve the prognosis.

See Also

• Endometrial cancer
• Uterus
• Cancer

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