Uterine serous carcinoma
Uterine Serous Carcinoma[edit | edit source]
Uterine serous carcinoma is a type of endometrial cancer that is characterized by its aggressive nature and poor prognosis. It is a subtype of endometrial carcinoma and is distinct from the more common endometrioid carcinoma.
Pathophysiology[edit | edit source]
Uterine serous carcinoma arises from the endometrium, the lining of the uterus. Unlike endometrioid carcinoma, which is often associated with estrogen exposure, uterine serous carcinoma is not typically linked to hormonal factors. It is thought to develop from endometrial intraepithelial carcinoma (EIC), a precursor lesion.
Clinical Presentation[edit | edit source]
Patients with uterine serous carcinoma often present with postmenopausal vaginal bleeding. Due to its aggressive nature, the cancer may have already spread beyond the uterus at the time of diagnosis. Other symptoms may include pelvic pain and ascites.
Diagnosis[edit | edit source]
Diagnosis is typically made through a combination of endometrial biopsy, imaging studies, and histopathological examination. On microscopic examination, uterine serous carcinoma is characterized by papillary structures and high-grade nuclear atypia.
Treatment[edit | edit source]
The treatment of uterine serous carcinoma often involves a combination of surgery, chemotherapy, and radiation therapy. Surgical management usually includes a hysterectomy with bilateral salpingo-oophorectomy and staging procedures. Due to the high risk of recurrence, adjuvant chemotherapy and radiation therapy are commonly employed.
Prognosis[edit | edit source]
The prognosis for uterine serous carcinoma is generally poor compared to other types of endometrial cancer. This is due to its aggressive nature and tendency to present at an advanced stage. The five-year survival rate is significantly lower than that for endometrioid carcinoma.
Related Pages[edit | edit source]
Uterine papillary serous carcinoma, low magnification
Uterine serous carcinoma, high magnification
Histopathology of serous carcinoma of uterus
Serous carcinoma cytology
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