XCT-790

Chemical structure of XCT-790

XCT-790 is a chemical compound known for its role as a selective inverse agonist of the estrogen-related receptor alpha (ERR_). It is primarily used in research settings to study the function of ERR_, a member of the nuclear receptor family of intracellular transcription factors.

Mechanism of Action

XCT-790 functions by binding to the ligand-binding domain of ERR_, thereby inhibiting its activity. ERR_ is an orphan nuclear receptor, meaning it does not have a known endogenous ligand. XCT-790's ability to act as an inverse agonist makes it a valuable tool for investigating the physiological and pathological roles of ERR_ in various tissues.

Biological Significance

ERR_ is involved in the regulation of energy metabolism, mitochondrial biogenesis, and oxidative phosphorylation. It is highly expressed in tissues with high energy demands, such as the heart, skeletal muscle, and brown adipose tissue. By modulating ERR_ activity, XCT-790 can influence metabolic pathways and has been used to study conditions such as obesity, diabetes, and cancer.

Research Applications

XCT-790 is utilized in laboratory research to:

• Investigate the role of ERR_ in metabolic disorders.
• Study the effects of ERR_ inhibition on cancer cell proliferation and survival.
• Explore the potential therapeutic applications of ERR_ modulation in cardiovascular diseases.

Safety and Handling

As with many research chemicals, XCT-790 should be handled with care. Appropriate safety protocols should be followed, including the use of personal protective equipment (PPE) and working in a well-ventilated area or fume hood.

Related Pages

• Estrogen-related receptor alpha
• Nuclear receptor
• Metabolic regulation
• Inverse agonist