5-Oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid
5-Oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) is a biologically active lipid derived from the arachidonic acid pathway. It is a potent eicosanoid that plays a significant role in inflammatory responses and immune system regulation.
Structure and Synthesis[edit | edit source]
5-Oxo-ETE is a 20-carbon polyunsaturated fatty acid with four double bonds, specifically in the 6E, 8Z, 11Z, and 14Z positions. It is synthesized from 5-hydroxyeicosatetraenoic acid (5-HETE) through the action of 5-hydroxyeicosanoid dehydrogenase (5-HEDH), an enzyme that catalyzes the oxidation of the hydroxyl group at the 5th carbon to a keto group.
Biological Function[edit | edit source]
5-Oxo-ETE is known for its role in the activation of eosinophils, a type of white blood cell involved in allergic reactions and asthma. It acts by binding to the OXE receptor, a G-protein coupled receptor, which leads to the activation and chemotaxis of eosinophils. This makes 5-oxo-ETE a significant mediator in conditions such as asthma, allergic rhinitis, and other eosinophil-associated diseases.
Pathophysiological Role[edit | edit source]
In addition to its role in eosinophil activation, 5-oxo-ETE is involved in the regulation of other immune cells, including neutrophils and monocytes. It has been implicated in the pathogenesis of various inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease.
Clinical Implications[edit | edit source]
Due to its potent effects on eosinophils and other immune cells, 5-oxo-ETE is a target for therapeutic intervention in diseases characterized by excessive inflammation and immune response. Inhibitors of 5-oxo-ETE synthesis or its receptor antagonists are being explored as potential treatments for asthma and other inflammatory conditions.
Research Directions[edit | edit source]
Ongoing research is focused on understanding the detailed mechanisms of 5-oxo-ETE action, its role in various diseases, and the development of specific inhibitors or antagonists that can modulate its activity for therapeutic purposes.
Also see[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
