Adolescent idiopathic scoliosis

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Adolescent Idiopathic Scoliosis (AIS) is a medical condition characterized by an abnormal lateral curvature of the spine that appears in children aged 10 to 18 years. The term "idiopathic" means the exact cause of the scoliosis is unknown, although it is believed to involve a combination of genetic and environmental factors. AIS is the most common type of scoliosis, accounting for about 80% of all cases.

Causes and Risk Factors

The exact cause of AIS remains unclear, but it is thought to involve genetic predisposition and possibly environmental triggers. Studies have identified several genes associated with an increased risk of developing scoliosis, suggesting a hereditary component. Additionally, factors such as gender (females are more likely to develop severe scoliosis), age (the risk increases with the onset of puberty), and family history are significant risk factors for AIS.

Symptoms and Diagnosis

The primary symptom of AIS is a visible curve in the spine, which can be detected through physical examination. Other symptoms may include uneven shoulders, a prominent rib hump, and an uneven waistline. In most cases, AIS is asymptomatic and does not cause pain or discomfort. Diagnosis typically involves a physical examination followed by imaging tests, such as an X-ray, to assess the severity of the curve, measured in degrees using the Cobb angle.

Treatment

The treatment for AIS depends on the severity of the curve, the age of the patient, and whether the spine is still growing. Treatment options include observation, bracing, and surgery. Observation is recommended for curves less than 20 degrees. Bracing is often used for curves between 20 and 40 degrees in patients who are still growing, to prevent further progression of the curve. Surgery, specifically spinal fusion, may be recommended for severe curves (greater than 40-45 degrees) or for curves that continue to progress despite bracing.

Prognosis

The prognosis for individuals with AIS varies. Mild curves are unlikely to progress significantly and often do not require treatment. Moderate curves may progress with growth and require intervention to prevent further curvature. Severe curves can lead to respiratory and cardiovascular issues if left untreated. However, with early detection and appropriate treatment, most individuals with AIS lead healthy, active lives.

Epidemiology

AIS affects 2-3% of the population under the age of 18. It is more common in females than males, with females being more likely to have curves that progress to a severity requiring treatment.

Research and Future Directions

Research into AIS continues to focus on understanding the genetic causes, improving diagnostic methods, and developing less invasive treatment options. Advances in genetic testing may lead to earlier identification of individuals at risk, allowing for proactive monitoring and intervention. Additionally, new technologies in bracing and minimally invasive surgical techniques hold promise for improving outcomes for patients with AIS.