Bumc pharm

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C: Pharmacology
Q: Combined oral contraceptives usually consist of an estrogen and ...
A: A progestin
3: Steroids
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: Flutamide is __
A: An antagonist at the androgen receptor that is used for palliative treatment of prostatic cancer.
3: Steroids
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: Tamoxifen is a selective estrogen-receptor modulator that acts therapeutically as an estrogen ... in bone and as an estrogen ... in breast
A: -agonist in bone//-antagonist in breast.
3: Steroids
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: Receptors for estrogens, progestins, and androgens are classified as __
A: Ligand-activated transcription factors
3: Steroids
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: The first FDA approved recombinant protein therapeutic was ...
A: Human insulin.
3: History
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: Rational drug design was used to discover ...
A: Indinavir.
3: History
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: In the first FDA approved gene therapy protocol, gene delivery was accomplished using ... ...
A: A retroviral vector.
3: History
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: The rate limiting enzyme in the synthesis of dopamine is ... ...
A: Tyrosine hydroxylase.
3: Biochemistry
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: The following structures belong to the basal ganglia __ [4]
A: -Striatum//-Globus Pallidum//-Substantia Nigra//-SubThalamus
3: NeuroAnatomy
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: The subthalamic neurons, which project to the output structures of the basal ganglia, are ...
A: Glutamatergic
3: Neuro
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: The symptoms of Parkinson’s disease are associated with an excessive __
A: Inhibition of thalamo-cortical neurons.
3: Neuro
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: Most recent research has concluded that the critical neurotransmitter or neuropeptide and brain areas involved in the rewarding effects of abuse substances are ... and the nucl. ...
A: -Dopamine//-nucl. Accumbens
3: CNS
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: Benzodiazepines can be distinguished from barbiturates because of the following characteristics:
A: Overdose from benzodiazepines can be effectively treated by administration of the benzodiazepine antagonist, flumazenil, while there is no antidote for barbiturate overdose.
3: CNS
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: A major problem in the treatment of anxiety disorders is the development of tolerance to longterm treatment. Tolerance can be reduced by which therapeutic regimen?
A: Use of short-acting benzodiazepines and partial modulators at the benzodiazepine site
3: CNS
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: The anxiolytic effect of benzodiazepines results from: 
A: Their ability to decrease the EC50 of GABA with respect to GABAA receptor mediated chloride influx
3: CNS
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: The major mechanism of terminating the usual interaction of dopamine with its receptors in the CNS is:
A: Reuptake by an energy dependent, electroneutral, high affinity transport process that can transport amphetamine.
3: CNS
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: The intensity of the euphoric effect of cocaine is:
A: Comparable after IV injection and smoking of crack cocaine because of rapid access to the CNS.
3: CNS
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: ... antagonist at adenosine receptors
A: Caffeine 
3: Mechanism of Action
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: Chemical class of amphetamine is ...
A: catecholamine
3: CNS
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: Analgesic agents are primarily distinguished from anesthetic agents in that: 
A: Analgesics are more selective for inhibition of the sensation of pain, relative to other sensory modalities.
3: CNS
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: Receptors which mediate the primary effects of opioids are: 
A: Membrane proteins activated by endogenous peptides.
3: CNS
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: The rate of onset of anesthesia from a drug like nitrous oxide or isoflurane is primarily determined by: 
A: The degree of solubility of the agent in blood (blood/gas solubility coefficient).
3: Pharmacodynamics
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: Resistance to antiviral agents is characterized by:
A: Increase in the IC50 of drugs, as has been shown for drugs acting on viral reverse transcriptase and viral protease.
3: Drug Resistance
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: The lack of selectivity of cancer chemotherapeutic agents is primarily manifested clinically by:
A: Impaired synthesis in the bone marrow of the cellular elements of blood.
3: Cancer Drugs
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: Drug-induced inhibition of dihydrofolate reductase: 
A: Inhibits DNA synthesis by depleting pools of thymidine nucleotides.
3: Cancer Drugs
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: The penicillin drugs are: 
A: Compounds with a four-membered B-lactam ring required for antibacterial efficacy.
3: Antibacterial
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: Sites of action of emetics used to treat poisonings include: 
A: Dopaminergic D2 receptors in the chemoreceptor trigger zone.
3: Misc
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: An example of an antidote used in poisonings to increase the inactivation rate of a toxic metabolite is: 
A: N-acetylcysteine. 
3: Misc
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: The LD50 of acetaminophen is increased in mice with deletions of genes for: 
A: Cyp1A2 and Cyp2E1.
3: Misc
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: The acute toxicity of organochlorine pesticides such as DDT results from: 
A: Excessive neural firing due to an effect on the neuronal sodium channel.
3: Poisoning
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: The significance of the interaction of a polycyclic aromatic hydrocarbon (PAH) such as benzopyrene with the Ah receptor is that: 
A: The rate of conversion of the PAH to mutagenic metabolites is increased.
3: Misc
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: A factor which significantly contributes to the toxic risk of DDT-like pesticides is: 
A: Chemical stability and high lipophilicity.
3: Misc
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: A reduction of blood supply to the brain or spinal cord: 
A: Initiates a process of excitotoxic cell death by causing the release of glutamate.
3: Apoptosis
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

C: Pharmacology
Q: The steroid-based drug candidate pregnanolone hemisuccinate:
A: Is probably neuroprotective, because it inhibits NMDA receptor activity.
3: Steroids
4: http://www.bumc.bu.edu/www/busm/pharmacology/imp/final-98.html

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