Cinitapride
Cinitapride is a gastroprokinetic agent and antiulcer agent of the benzamide class which is marketed in Spain and Mexico. It acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors.
Mechanism of action[edit | edit source]
Cinitapride has a dual mechanism of action. It works as an agonist of the 5-HT1 and 5-HT4 receptors, and as an antagonist of the 5-HT2 receptors. This dual action makes it effective in treating certain gastrointestinal conditions.
Uses[edit | edit source]
Cinitapride is used in the treatment of gastroesophageal reflux disease (GERD), non-ulcer dyspepsia, and as a prokinetic agent in conditions such as gastroparesis and functional dyspepsia.
Side effects[edit | edit source]
The most common side effects of cinitapride include dizziness, headache, diarrhea, and abdominal pain. In rare cases, it can cause extrapyramidal symptoms.
Contraindications[edit | edit source]
Cinitapride is contraindicated in patients with known hypersensitivity to the drug, and in those with gastrointestinal hemorrhage, mechanical obstruction, or perforation.
Interactions[edit | edit source]
Cinitapride may interact with other drugs such as anticholinergic medications, antipsychotic drugs, and antiarrhythmic drugs.
Pharmacokinetics[edit | edit source]
Cinitapride is rapidly absorbed from the gastrointestinal tract and undergoes extensive first-pass metabolism in the liver. It is excreted primarily in the urine.
See also[edit | edit source]
Cinitapride Resources | ||
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