Clopamide

From WikiMD's Wellness Encyclopedia

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Clopamide.svg

Clopamide' is a sulfonamide diuretic drug used primarily in the treatment of hypertension and edema. It belongs to the class of thiazide-like diuretics, which work by inhibiting the reabsorption of sodium and chloride ions in the distal convoluted tubules of the kidneys, leading to an increase in the excretion of water, sodium, and chloride.

Mechanism of Action[edit | edit source]

Clopamide acts on the distal convoluted tubule of the nephron in the kidney. By inhibiting the sodium-chloride symporter, it reduces the reabsorption of sodium and chloride ions. This action results in increased excretion of these ions, along with water, thereby reducing the volume of fluid in the blood vessels and lowering blood pressure.

Medical Uses[edit | edit source]

Clopamide is primarily used for:

Side Effects[edit | edit source]

Common side effects of clopamide include:

Contraindications[edit | edit source]

Clopamide should not be used in patients with:

Pharmacokinetics[edit | edit source]

Clopamide is well absorbed from the gastrointestinal tract. It is metabolized in the liver and excreted primarily in the urine. The half-life of clopamide is approximately 6-8 hours.

History[edit | edit source]

Clopamide was developed in the mid-20th century and has been used clinically for several decades. It is available in various formulations, including tablets and capsules.

See Also[edit | edit source]

References[edit | edit source]

External Links[edit | edit source]

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Contributors: Prab R. Tumpati, MD