Clopamide
Clopamide' is a sulfonamide diuretic drug used primarily in the treatment of hypertension and edema. It belongs to the class of thiazide-like diuretics, which work by inhibiting the reabsorption of sodium and chloride ions in the distal convoluted tubules of the kidneys, leading to an increase in the excretion of water, sodium, and chloride.
Mechanism of Action[edit]
Clopamide acts on the distal convoluted tubule of the nephron in the kidney. By inhibiting the sodium-chloride symporter, it reduces the reabsorption of sodium and chloride ions. This action results in increased excretion of these ions, along with water, thereby reducing the volume of fluid in the blood vessels and lowering blood pressure.
Medical Uses[edit]
Clopamide is primarily used for:
- Hypertension: It helps in lowering high blood pressure, thereby reducing the risk of stroke and myocardial infarction.
- Edema: It is used to treat fluid retention associated with conditions such as congestive heart failure, liver cirrhosis, and renal disease.
Side Effects[edit]
Common side effects of clopamide include:
- Hypokalemia (low potassium levels)
- Hyponatremia (low sodium levels)
- Hypercalcemia (high calcium levels)
- Hyperglycemia (high blood sugar levels)
- Hyperuricemia (high uric acid levels)
Contraindications[edit]
Clopamide should not be used in patients with:
- Severe renal impairment
- Severe hepatic impairment
- Hypersensitivity to sulfonamides
Pharmacokinetics[edit]
Clopamide is well absorbed from the gastrointestinal tract. It is metabolized in the liver and excreted primarily in the urine. The half-life of clopamide is approximately 6-8 hours.
History[edit]
Clopamide was developed in the mid-20th century and has been used clinically for several decades. It is available in various formulations, including tablets and capsules.
See Also[edit]
References[edit]
External Links[edit]
| Clopamide | |
|---|---|
|
| |
| Trade names | Brinaldix
|
| Metabolism | Hepatic
|
| Excretion | Renal
|
| Identifiers
| |
| PubChem | 2788 |
| DrugBank | DB08977 |
| ChemSpider | 2685 |
| UNII | 0U3X371QPL |
| KEGG | D07150 |
| ChEMBL | 2104660 |
| Chemical data
| |
| Chemical formula | C14H19N3O3S1Cl1
|
| SMILES | CC1CCCC(N1)NC(=O)C2=CC(=C(C=C2Cl)S(=O)(=O)N)C
|
| InChI | 1S/C14H19ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(13(8-11)15)22(16,20)21/h6-10H,3-5H2,1-2H3,(H2,16,20,21)(H,17,19)
|
| InChIKey | QXWYKJLNLSIPIN-UHFFFAOYSA-N
|
 | This medical article is a stub. You can help WikiMD by expanding the page. |
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
