Dihydrotestosterone undecanoate
Dihydrotestosterone undecanoate (DHTU) is a synthetic androgen and anabolic steroid and a dihydrotestosterone (DHT) ester. It is used in androgen replacement therapy primarily for the treatment of male hypogonadism, and is currently under research for use as a male contraceptive.
Chemistry[edit | edit source]
DHTU, also known as androstanolone undecanoate, is a synthetic estrane steroid and a derivative of DHT. It is more specifically a derivative of methyldihydrotestosterone (MDHT), which is itself a derivative of DHT. DHTU is a DHT ester that is C17β esterified with undecanoic acid.
Pharmacology[edit | edit source]
As a derivative of DHT, DHTU is a bioidentical hormone. It is an androgen, or an agonist of the androgen receptor, the biological target of androgens like testosterone and DHT. Unlike testosterone, DHT cannot be aromatized into an estrogen, and for this reason, DHTU, unlike testosterone undecanoate, does not have the capacity for estrogenic side effects.
Society and culture[edit | edit source]
DHTU is marketed and used clinically under brand names such as Aveed, Nebido, and Reandron 1000. It is available in certain countries, including in the United Kingdom, Australia, Spain, and Canada, but is not available in the United States.
See also[edit | edit source]
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