Froelich's syndrome
Froelich's Syndrome is a rare endocrine disorder characterized by obesity and delayed or absent puberty. It is also known as Adiposogenital Dystrophy.
Overview[edit | edit source]
Froelich's Syndrome was first described by the German physician Alfred Froelich in the early 20th century. The syndrome is characterized by a combination of obesity and hypogonadism, a condition in which the body produces little or no sex hormones. This results in delayed or absent puberty. Other symptoms may include growth retardation, small hands and feet, and a high-pitched voice.
Causes[edit | edit source]
The exact cause of Froelich's Syndrome is unknown, but it is believed to be due to a dysfunction in the hypothalamus, a small region of the brain that controls the pituitary gland. This dysfunction can result in a decrease in the production of gonadotropin-releasing hormone (GnRH), which in turn leads to a decrease in the production of sex hormones.
Diagnosis[edit | edit source]
Diagnosis of Froelich's Syndrome is based on the presence of the characteristic symptoms and may be confirmed by blood tests showing low levels of sex hormones. Imaging studies such as magnetic resonance imaging (MRI) may be used to check for abnormalities in the hypothalamus or pituitary gland.
Treatment[edit | edit source]
Treatment for Froelich's Syndrome typically involves hormone replacement therapy to compensate for the lack of sex hormones. This can help to stimulate puberty and promote normal sexual development. In some cases, surgery may be required to correct abnormalities in the hypothalamus or pituitary gland.
Prognosis[edit | edit source]
The prognosis for individuals with Froelich's Syndrome varies depending on the severity of the condition and the effectiveness of treatment. With appropriate treatment, most individuals can lead normal lives.
See also[edit | edit source]
NIH genetic and rare disease info[edit source]
Froelich's syndrome is a rare disease.
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Contributors: Prab R. Tumpati, MD
