Gianotti-Crosti syndrome

Gianotti-Crosti Syndrome (GCS), also known as Infantile Papular Acrodermatitis, is a rare skin disorder that primarily affects children. It was first described by the Italian dermatologists Ferdinando Gianotti and Agostino Crosti in 1955.

Etiology

The exact cause of Gianotti-Crosti Syndrome is unknown. However, it is often associated with viral infections, particularly Epstein-Barr, Hepatitis B, and Cytomegalovirus. Other potential triggers include vaccinations and bacterial infections.

Clinical Features

Gianotti-Crosti Syndrome is characterized by the sudden onset of red, itchy, flat-topped bumps (papules) on the skin. These papules are typically symmetrical and are most commonly found on the face, buttocks, and extremities. Other symptoms may include mild fever, fatigue, and enlarged lymph nodes.

Diagnosis

Diagnosis of Gianotti-Crosti Syndrome is primarily based on clinical examination and patient history. Laboratory tests may be performed to identify associated viral infections. Skin biopsy is rarely needed but can be used to confirm the diagnosis.

Treatment

There is no specific treatment for Gianotti-Crosti Syndrome. The condition is self-limiting and usually resolves within 1-2 months. Symptomatic treatment may include topical corticosteroids to reduce itching and inflammation.

Prognosis

The prognosis for Gianotti-Crosti Syndrome is generally good. Most children recover completely without any long-term complications. However, the rash may persist for several weeks to months before it completely disappears.

Epidemiology

Gianotti-Crosti Syndrome is rare and occurs worldwide. It is most common in children aged 1-6 years, but can occur at any age. Both males and females are equally affected.

See Also

• List of cutaneous conditions
• Dermatology
• Pediatrics

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NIH genetic and rare disease info

• NIH info on Gianotti-Crosti syndrome

Gianotti-Crosti syndrome is a rare disease.

Gianotti-Crosti syndrome Resources
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