Gianotti-Crosti syndrome
Gianotti-Crosti Syndrome (GCS), also known as Infantile Papular Acrodermatitis, is a rare skin disorder that primarily affects children. It was first described by the Italian dermatologists Ferdinando Gianotti and Agostino Crosti in 1955.
Etiology[edit | edit source]
The exact cause of Gianotti-Crosti Syndrome is unknown. However, it is often associated with viral infections, particularly Epstein-Barr, Hepatitis B, and Cytomegalovirus. Other potential triggers include vaccinations and bacterial infections.
Clinical Features[edit | edit source]
Gianotti-Crosti Syndrome is characterized by the sudden onset of red, itchy, flat-topped bumps (papules) on the skin. These papules are typically symmetrical and are most commonly found on the face, buttocks, and extremities. Other symptoms may include mild fever, fatigue, and enlarged lymph nodes.
Diagnosis[edit | edit source]
Diagnosis of Gianotti-Crosti Syndrome is primarily based on clinical examination and patient history. Laboratory tests may be performed to identify associated viral infections. Skin biopsy is rarely needed but can be used to confirm the diagnosis.
Treatment[edit | edit source]
There is no specific treatment for Gianotti-Crosti Syndrome. The condition is self-limiting and usually resolves within 1-2 months. Symptomatic treatment may include topical corticosteroids to reduce itching and inflammation.
Prognosis[edit | edit source]
The prognosis for Gianotti-Crosti Syndrome is generally good. Most children recover completely without any long-term complications. However, the rash may persist for several weeks to months before it completely disappears.
Epidemiology[edit | edit source]
Gianotti-Crosti Syndrome is rare and occurs worldwide. It is most common in children aged 1-6 years, but can occur at any age. Both males and females are equally affected.
See Also[edit | edit source]
Dermatology and Rheumatologic diseases A - Z
A | B | C | E | F | G | H | I | J | K | L | M | O | P | R | S | T | V
Pediatric glossary of terms | Glossary of medical terms | Dictionary of pediatrics
NIH genetic and rare disease info[edit source]
Gianotti-Crosti syndrome is a rare disease.
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Contributors: Prab R. Tumpati, MD
