Glucocorticoid resistance

Glucocorticoid resistance is a condition characterized by a decrease in the sensitivity of glucocorticoid receptors, which leads to a reduction in the physiological response to glucocorticoid hormones. This condition can be either primary, due to a genetic mutation, or secondary, due to factors such as stress, obesity, or illness.

Causes

The primary cause of glucocorticoid resistance is a genetic mutation in the glucocorticoid receptor gene. This mutation can lead to a decrease in the number of functional receptors, a decrease in the affinity of the receptor for glucocorticoids, or a decrease in the efficiency of the receptor in transmitting the signal to the cell nucleus.

Secondary glucocorticoid resistance can be caused by a variety of factors, including chronic stress, obesity, and certain illnesses. These factors can lead to an increase in the production of cortisol, which can in turn lead to a decrease in the sensitivity of the glucocorticoid receptor.

Symptoms

The symptoms of glucocorticoid resistance can vary widely, depending on the severity of the condition and the underlying cause. Common symptoms can include fatigue, weight gain, depression, and a decreased ability to handle stress. In severe cases, glucocorticoid resistance can lead to Cushing's syndrome, a condition characterized by a high level of cortisol in the blood.

Treatment

The treatment for glucocorticoid resistance depends on the underlying cause. In cases of primary glucocorticoid resistance caused by a genetic mutation, treatment may involve the use of drugs that increase the sensitivity of the glucocorticoid receptor. In cases of secondary glucocorticoid resistance, treatment may involve addressing the underlying cause, such as reducing stress or treating the underlying illness.

See also

• Glucocorticoid
• Glucocorticoid receptor
• Cushing's syndrome

Glucocorticoid resistance Resources
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