Goblet cell carcinoid
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| Synonyms | Crypt cell carcinoma, neuroendocrine tumour with goblet cell differentiation |
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The goblet cell carcinoid (GCC) is a rare biphasic gastrointestinal tract tumour that consists of a neuroendocrine component and a conventional carcinoma, histologically arising from Paneth cells.[1]
Sign and symptoms[edit | edit source]
GCCs may present as appendicitis.
Diagnosis[edit | edit source]
GCCs are diagnosed by pathology. They have a characteristic biphasic appearance which includes (1) goblet cell-like cells, and (2) neuroendocrine-type nuclear chromatin (stippled chromatin).
Prognosis[edit | edit source]
GCCs have an aggressive course compared to other appendiceal neuroendocrine tumours.[1]
Treatment[edit | edit source]
GCCs are treated with surgery.
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Contributors: Prab R. Tumpati, MD
