Goblet cell carcinoid

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The goblet cell carcinoid (GCC) is a rare biphasic gastrointestinal tract tumour that consists of a neuroendocrine component and a conventional carcinoma, histologically arising from Paneth cells.[1]

Sign and symptoms[edit | edit source]

GCCs may present as appendicitis.

Diagnosis[edit | edit source]

Micrograph of a goblet cell carcinoid. H&E stain.

GCCs are diagnosed by pathology. They have a characteristic biphasic appearance which includes (1) goblet cell-like cells, and (2) neuroendocrine-type nuclear chromatin (stippled chromatin).

Prognosis[edit | edit source]

GCCs have an aggressive course compared to other appendiceal neuroendocrine tumours.[1]

Treatment[edit | edit source]

GCCs are treated with surgery.

See also[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1

External links[edit | edit source]

Classification
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Contributors: Prab R. Tumpati, MD