KLF10

KLF10 (Krüppel-like factor 10), also known as TIEG1 (TGF-beta inducible early growth response protein 1), is a protein that in humans is encoded by the KLF10 gene. It is a member of the Krüppel-like factor (KLF) family of transcription factors, which regulate numerous biological processes including cell proliferation, differentiation, apoptosis, and growth.

Function

KLF10 is a zinc finger transcription factor that binds to GC-rich regions of DNA. It is involved in the regulation of cell growth and differentiation, particularly in response to transforming growth factor beta (TGF-beta) signaling. KLF10 acts as a mediator of TGF-beta induced growth inhibition and apoptosis in epithelial cells.

Clinical significance

Alterations in the expression of KLF10 have been associated with several diseases. For example, reduced KLF10 expression has been observed in osteoporosis, suggesting a role in bone metabolism. Additionally, KLF10 has been implicated in the pathogenesis of diabetes, as it regulates insulin transcription and secretion in pancreatic beta-cells.

Research

Research into KLF10 has focused on its role in various biological processes and diseases. For instance, studies have investigated its function in cardiovascular disease, cancer, and neurodegenerative diseases. Further research is needed to fully understand the mechanisms by which KLF10 influences these conditions.

See also

• Krüppel-like factors
• Transcription factor
• Transforming growth factor beta