MORM syndrome
MORM syndrome is a rare genetic disorder characterized by a combination of mental retardation, obesity, retinal dystrophy, and micropenis. The name MORM is an acronym derived from these primary features. This syndrome is inherited in an autosomal recessive manner.
Clinical Features[edit | edit source]
Individuals with MORM syndrome typically present with the following clinical features:
- **Mental Retardation**: A significant impairment in cognitive function and adaptive behaviors.
- **Obesity**: Excessive body weight, often beginning in childhood.
- **Retinal Dystrophy**: Progressive degeneration of the retina, leading to vision impairment or blindness.
- **Micropenis**: An abnormally small penis.
Genetics[edit | edit source]
MORM syndrome is caused by mutations in a specific gene, which is inherited in an autosomal recessive pattern. This means that an individual must inherit two copies of the mutated gene, one from each parent, to be affected by the disorder. Carriers, who have only one copy of the mutated gene, typically do not show symptoms.
Diagnosis[edit | edit source]
The diagnosis of MORM syndrome is based on clinical evaluation, family history, and genetic testing. The presence of the characteristic features, along with genetic confirmation, is essential for a definitive diagnosis.
Management[edit | edit source]
There is currently no cure for MORM syndrome. Management focuses on addressing the individual symptoms and may include:
- Special education programs and therapies to support cognitive development.
- Nutritional and lifestyle interventions to manage obesity.
- Regular ophthalmologic evaluations to monitor and manage retinal dystrophy.
- Hormonal treatments or surgical options for micropenis, if necessary.
Prognosis[edit | edit source]
The prognosis for individuals with MORM syndrome varies depending on the severity of the symptoms and the effectiveness of the management strategies. Early intervention and supportive care can improve the quality of life for affected individuals.
See Also[edit | edit source]
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD