N-methyltryptamine

N-Methyltryptamine (NMT) is a member of the tryptamine family. It is a naturally occurring alkaloid that is structurally similar to other tryptamines.

Chemistry[edit | edit source]

N-Methyltryptamine is a derivative of the amino acid tryptophan. It is a mono-methylated tryptamine, structurally similar to other tryptamines such as DMT, DET, and MET. The chemical formula of NMT is C12H16N2.

Biosynthesis[edit | edit source]

N-Methyltryptamine is biosynthesized via the action of the enzyme tryptamine N-methyltransferase on tryptamine. This reaction is part of the larger biosynthetic pathway for the production of dimethyltryptamine from tryptophan.

Pharmacology[edit | edit source]

N-Methyltryptamine acts as a serotonin receptor agonist. It has been found to inhibit serotonin reuptake, and thus may act as a serotonin-norepinephrine reuptake inhibitor.

Natural occurrence[edit | edit source]

N-Methyltryptamine has been found in a variety of plants and animals, including certain species of Acacia, Virola, and Phalaris.

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v t e Psychoactive drugs
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Depressants	Alcohol Barbiturate Benzodiazepine GHB Opiate Opioid
Hallucinogens	LSD Psilocybin MDMA Mescaline DMT
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Research and Treatment	Drug addiction Psychoactive drug research Drug rehabilitation Harm reduction
Legal aspects	Drug policy of the Netherlands Legal status of psilocybin mushrooms Legal status of Salvia divinorum
This psychoactive drug related article is a stub.

v t e Serotonin receptor agonists
[[5-HT₁ receptor\|5-HT₁]]	[[5-HT_1A receptor\|5-HT_1A]]: Buspirone, Flesinoxan, Gepirone, Ipsapirone, Tandospirone [[5-HT_1B receptor\|5-HT_1B]]: Zolmitriptan, Sumatriptan, Rizatriptan, Eletriptan, Naratriptan [[5-HT_1D receptor\|5-HT_1D]]: Lasmiditan, Ergotamine, Methysergide [[5-HT_1E receptor\|5-HT_1E]]: (specific agonists not widely recognized) [[5-HT_1F receptor\|5-HT_1F]]: LY-334,370, Collybolide
[[5-HT₂ receptor\|5-HT₂]]	[[5-HT_2A receptor\|5-HT_2A]]: LSD, Psilocybin, DOI, DOM, DPT [[5-HT_2B receptor\|5-HT_2B]]: BW-723C86, Fenfluramine, Norfenfluramine [[5-HT_2C receptor\|5-HT_2C]]: Lorcaserin, WAY-161,503, MK-212
[[5-HT₃ receptor\|5-HT₃]]	Ondansetron, Granisetron, Palonosetron, Tropisetron
[[5-HT₄ receptor\|5-HT₄]]	Cisapride, Metoclopramide, Prucalopride, Tegaserod
[[5-HT₅ receptor\|5-HT₅]]	[[5-HT_5A receptor\|5-HT_5A]]: (specific agonists not widely recognized) [[5-HT_5B receptor\|5-HT_5B]]: (receptor exists in rodents, not in humans)
[[5-HT₆ receptor\|5-HT₆]]	E-6801, WAY-181,187, WAY-208,466
[[5-HT₇ receptor\|5-HT₇]]	AS-19, E-55888, LP-211, SB-269,970
This serotonin receptor related article is a stub.