Ollier's disease
Ollier's disease is a rare, nonhereditary skeletal disorder characterized by multiple enchondromas, benign cartilage tumors that originate from the growth plate. This condition is named after the French physician Louis Xavier Édouard Léopold Ollier, who first described it in the 19th century.
Epidemiology[edit | edit source]
Ollier's disease is a rare condition, with an estimated prevalence of 1 in 100,000. It affects males and females equally and is usually diagnosed in childhood, typically between the ages of 5 and 15.
Symptoms[edit | edit source]
The most common symptoms of Ollier's disease are bone deformities and limb length discrepancy. The enchondromas can cause the affected bones to grow at different rates, leading to physical deformities. Pain, swelling, and fractures can also occur. In some cases, the enchondromas can transform into chondrosarcoma, a type of bone cancer.
Diagnosis[edit | edit source]
The diagnosis of Ollier's disease is usually made based on clinical findings and imaging studies. X-rays can reveal the characteristic enchondromas, and MRI may be used to assess the extent of the disease and to monitor for malignant transformation.
Treatment[edit | edit source]
There is no cure for Ollier's disease, and treatment is focused on managing symptoms and preventing complications. This may include surgery to correct deformities or to remove enchondromas that are causing pain or have a high risk of malignant transformation.
Prognosis[edit | edit source]
The prognosis for individuals with Ollier's disease varies. Some people may have mild symptoms and lead normal lives, while others may experience significant physical disabilities. The risk of malignant transformation to chondrosarcoma is estimated to be around 25-30%.
See also[edit | edit source]
NIH genetic and rare disease info[edit source]
Ollier's disease is a rare disease.
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