PARP-1
PARP-1 (Poly (ADP-ribose) polymerase 1) is a protein that in humans is encoded by the PARP1 gene. It is one of the PARP family of proteins, which play a role in DNA repair and programmed cell death.
Function[edit | edit source]
PARP-1 is involved in a number of cellular processes, including DNA repair, genomic stability, and programmed cell death. It is activated by DNA breaks and uses NAD+ as a substrate to synthesize poly (ADP-ribose) (PAR). PAR then interacts with DNA repair proteins to facilitate DNA repair.
Clinical significance[edit | edit source]
PARP-1 has been implicated in a number of diseases, including cancer, ischemic injuries, inflammation, and neurodegenerative diseases. In cancer, PARP-1 is involved in the repair of DNA damage, and inhibitors of PARP-1 have been developed as a treatment for certain types of cancer.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- PARP1 at the US National Library of Medicine Medical Subject Headings (MeSH)
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Contributors: Prab R. Tumpati, MD
