PARP-1

PARP-1 (Poly (ADP-ribose) polymerase 1) is a protein that in humans is encoded by the PARP1 gene. It is one of the PARP family of proteins, which play a role in DNA repair and programmed cell death.

Function

PARP-1 is involved in a number of cellular processes, including DNA repair, genomic stability, and programmed cell death. It is activated by DNA breaks and uses NAD+ as a substrate to synthesize poly (ADP-ribose) (PAR). PAR then interacts with DNA repair proteins to facilitate DNA repair.

Clinical significance

PARP-1 has been implicated in a number of diseases, including cancer, ischemic injuries, inflammation, and neurodegenerative diseases. In cancer, PARP-1 is involved in the repair of DNA damage, and inhibitors of PARP-1 have been developed as a treatment for certain types of cancer.

See also

• PARP
• DNA repair
• Cancer

External links

• PARP1 at the US National Library of Medicine Medical Subject Headings (MeSH)

PARP-1 Resources
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