Robert B. Darnell

Professor Robert Darnell

Robert B. Darnell is an American neuroscientist and physician known for his pioneering work in the field of neuro-oncology and RNA biology. He is a leading expert in the study of paraneoplastic syndromes and the role of RNA-binding proteins in the nervous system.

Early Life and Education

Robert B. Darnell was born in New York City. He completed his undergraduate studies at Columbia University, where he earned a degree in biochemistry. He then attended Washington University School of Medicine in St. Louis, where he received his M.D. and Ph.D. degrees.

Career

Darnell began his career as a neurologist and neuro-oncologist at The Rockefeller University, where he also established his own laboratory. His research has focused on understanding the molecular mechanisms underlying paraneoplastic neurological disorders (PNDs), which are rare, autoimmune diseases triggered by an immune response to cancer.

Research Contributions

Darnell's work has significantly advanced the understanding of RNA-binding proteins and their role in neuronal function and disease. He discovered that certain autoantibodies in patients with PNDs target neuronal antigens, leading to the identification of several key RNA-binding proteins such as Nova proteins.

His research has also contributed to the development of new diagnostic tools and potential therapeutic strategies for neurodegenerative diseases and cancer.

Honors and Awards

Robert B. Darnell has received numerous awards and honors for his contributions to neuroscience and medicine. He is a member of the National Academy of Sciences and the Institute of Medicine.

Personal Life

Darnell resides in New York City with his family. He continues to conduct research and teach at The Rockefeller University.

See Also

• Neuro-oncology
• RNA-binding protein
• Paraneoplastic syndrome
• Neurodegenerative disease