Vitamin b12

Vitamin B12

Chemical structure of Vitamin B12

Vitamin B12, also known as cobalamin, is a water-soluble vitamin that plays an essential role in the functioning of the brain and nervous system, and in the formation of blood. It is one of the eight B vitamins. Vitamin B12 is involved in the metabolism of every cell of the human body, especially affecting DNA synthesis, fatty acid and amino acid metabolism.

Sources

Vitamin B12 is not produced by plants or animals, but by microorganisms. The primary sources of vitamin B12 for humans are animal products, including meat, milk, eggs, and fish. Notably, plant foods do not contain vitamin B12 except when they are contaminated by microorganisms or have vitamin B12 added to them. Thus, vegetarians and especially vegans are at risk of vitamin B12 deficiency and may need to take dietary supplements or eat B12-fortified foods.

Absorption and Metabolism

The absorption of vitamin B12 from the diet involves a complex process. Initially, gastric acid in the stomach separates vitamin B12 from the protein to which vitamin B12 is attached in food. After separation, vitamin B12 combines with a protein made by the stomach called intrinsic factor and is then absorbed by the body. This process is efficient only when the intrinsic factor is present and the stomach and intestines are functioning properly.

Deficiency

Vitamin B12 deficiency can lead to several health issues, including anemia, neuropathy, and irreversible nervous system damage. Early symptoms of deficiency may include fatigue, weakness, constipation, loss of appetite, and weight loss. If left untreated, it can also lead to neurological changes such as numbness and tingling in the hands and feet, difficulty maintaining balance, depression, confusion, dementia, poor memory, and soreness of the mouth or tongue.

Health Benefits

Vitamin B12 has numerous health benefits. It helps in the production of red blood cells and prevents megaloblastic anemia, a condition that makes people tired and weak. Additionally, it supports bone health and may prevent osteoporosis. Research suggests that vitamin B12 can also improve mood and symptoms of depression by playing a role in the synthesis of serotonin, a chemical responsible for regulating mood.

Supplementation

For those unable to get enough vitamin B12 through diet alone, or who have absorption issues, supplementation may be necessary. Vitamin B12 supplements come in the form of pills, sublingual tablets, or injections. It is important for individuals, especially those who are pregnant, breastfeeding, elderly, or have certain medical conditions, to consult with a healthcare provider before starting any supplementation.

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