7α-methylestr-4-ene-3,17-dione

7α-Methylestr-4-ene-3,17-dione is a steroid that is classified as a prohormone. It is also known as 7-alpha-methyl-19-nortestosterone (MENT), a synthetic, orally active anabolic-androgenic steroid (AAS) that is used in androgen replacement therapy (ART) mainly for the treatment of male hypogonadism.

Chemical Structure and Properties

7α-Methylestr-4-ene-3,17-dione is a derivative of nandrolone. It has a methyl group added at the 7-alpha position. This modification enhances the androgenic potency of the steroid and its oral bioavailability. The chemical formula of 7α-Methylestr-4-ene-3,17-dione is C20H28O2 and its molecular weight is 300.44 g/mol.

Pharmacology

7α-Methylestr-4-ene-3,17-dione is converted in the body to its active form, 7α-methyl-19-nortestosterone. This active metabolite binds to and activates the androgen receptor, exerting its androgenic and anabolic effects. It has a higher affinity for the androgen receptor compared to testosterone and nandrolone, and does not bind to sex hormone-binding globulin (SHBG), which makes it more bioavailable.

Medical Uses

7α-Methylestr-4-ene-3,17-dione is used in androgen replacement therapy mainly for the treatment of male hypogonadism. It is also being investigated for potential use in male contraception.

Side Effects

Potential side effects of 7α-Methylestr-4-ene-3,17-dione include acne, hair loss, prostate enlargement, and increased risk of cardiovascular disease. As with all anabolic steroids, there is also the risk of psychological dependence.

See Also

• Anabolic steroid
• Androgen replacement therapy
• Hypogonadism