Aggressive NK-cell leukemia
(Redirected from ANKL)
| Aggressive NK-cell leukemia | |
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Aggressive NK-cell leukemia is a rare and rapidly progressing form of leukemia characterized by the proliferation of natural killer cells. It is considered a subtype of large granular lymphocyte leukemia.
Signs and Symptoms[edit | edit source]
Patients with aggressive NK-cell leukemia often present with systemic symptoms such as fever, weight loss, night sweats, and fatigue. Other symptoms may include hepatosplenomegaly and lymphadenopathy.
Complications[edit | edit source]
This condition can lead to severe complications, including hemophagocytic lymphohistiocytosis (HLH), a life-threatening condition characterized by excessive immune activation and organ failure.
Causes[edit | edit source]
The exact cause of aggressive NK-cell leukemia is not well understood, but it is often associated with genetic mutations and viral infections, particularly the Epstein-Barr virus (EBV).
Diagnosis[edit | edit source]
Diagnosis typically involves a combination of blood tests, bone marrow biopsy, and immunophenotyping to identify the abnormal NK cells. Cytogenetic analysis may also be performed to detect specific genetic abnormalities.
Treatment[edit | edit source]
Treatment options are limited and often include chemotherapy and stem cell transplant. The prognosis for aggressive NK-cell leukemia is generally poor, with a high rate of relapse and resistance to treatment.
Epidemiology[edit | edit source]
Aggressive NK-cell leukemia is a rare disease, with a higher prevalence in East Asia. It affects both children and adults, with a slight male predominance.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
