Aggressive NK-cell leukemia
(Redirected from ANKL)
| Aggressive NK-cell leukemia | |
|---|---|
| Synonyms | N/A |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Fever, weight loss, night sweats, hepatosplenomegaly, lymphadenopathy |
| Complications | Hemophagocytic lymphohistiocytosis, multi-organ failure |
| Onset | Typically in young adults |
| Duration | Acute |
| Types | N/A |
| Causes | Genetic mutations, Epstein-Barr virus |
| Risks | Immunosuppression, Asian descent |
| Diagnosis | Blood test, bone marrow biopsy, immunophenotyping |
| Differential diagnosis | T-cell leukemia, B-cell lymphoma, infectious mononucleosis |
| Prevention | N/A |
| Treatment | Chemotherapy, hematopoietic stem cell transplantation |
| Medication | N/A |
| Prognosis | Poor |
| Frequency | Rare |
| Deaths | N/A |
| Aggressive NK-cell leukemia | |
|---|---|
| ICD-10 | |
| ICD-9 | |
| DiseasesDB | |
| MedlinePlus | |
| eMedicine | |
| MeSH ID | |
Aggressive NK-cell leukemia is a rare and rapidly progressing form of leukemia characterized by the proliferation of natural killer cells. It is considered a subtype of large granular lymphocyte leukemia.
Signs and Symptoms[edit | edit source]
Patients with aggressive NK-cell leukemia often present with systemic symptoms such as fever, weight loss, night sweats, and fatigue. Other symptoms may include hepatosplenomegaly and lymphadenopathy.
Complications[edit | edit source]
This condition can lead to severe complications, including hemophagocytic lymphohistiocytosis (HLH), a life-threatening condition characterized by excessive immune activation and organ failure.
Causes[edit | edit source]
The exact cause of aggressive NK-cell leukemia is not well understood, but it is often associated with genetic mutations and viral infections, particularly the Epstein-Barr virus (EBV).
Diagnosis[edit | edit source]
Diagnosis typically involves a combination of blood tests, bone marrow biopsy, and immunophenotyping to identify the abnormal NK cells. Cytogenetic analysis may also be performed to detect specific genetic abnormalities.
Treatment[edit | edit source]
Treatment options are limited and often include chemotherapy and stem cell transplant. The prognosis for aggressive NK-cell leukemia is generally poor, with a high rate of relapse and resistance to treatment.
Epidemiology[edit | edit source]
Aggressive NK-cell leukemia is a rare disease, with a higher prevalence in East Asia. It affects both children and adults, with a slight male predominance.
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
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