Abametapir

What abametapir?[edit | edit source]

Abametapir (Xeglyze) is a prescription medicine used to get rid of head lice in people 6 months of age and older.

This medicine is indicated for the topical treatment of head lice infestation in patients 6 months of age and older.
This medicine should be used in the context of an overall lice management program:
Wash (with hot water) or dry-clean all recently worn clothing, hats, used bedding and towels
Wash personal care items such as combs, brushes, and hair clips in hot water
Use a fine-tooth comb or special nit comb to remove dead lice and nits

Abametapir (5,5’-dimethyl 2,2’-bipyridinyl) is a metalloproteinase inhibitor.
Metalloproteinases have a role in physiological processes critical to egg development and survival of lice.

Use is not recommended in pediatric patients under 6 months of age because of the potential for increased systemic absorption.

For topical use only.
Not for oral, ophthalmic, or intravaginal use.
Shake well before use.
Apply XEGLYZE to dry hair in an amount sufficient (up to the full content of one bottle) to thoroughly coat the hair and scalp.
Avoid contact with eyes.
Massage XEGLYZE into the scalp and throughout the hair; leave on the hair and scalp for 10 minutes and then rinse off with warm water.
Treatment with XEGLYZE involves a single application.
Discard any unused product.
Do not flush contents down sink or toilet.

This medicine is available in fallowing doasage form:

This medicine is available in fallowing brand namesː

Common possible side effects of this medicine include:

Administer only under direct supervision of an adult.
systemic exposure to benzyl alcohol has been associated with serious adverse reactions and death in neonates and low birth-weight infants.
Safety and effectiveness in pediatric patients below the age of 6 months have not been established.

Ingestion of benzyl alcohol in large quantities may result in gastrointestinal (nausea, vomiting, diarrhea) and central nervous system (headache, ataxia, convulsions, coma) adverse reactions.
Serious adverse reactions may include respiratory depression and death.
If accidentally swallowed, advise the patient or the caregiver to call their Poison Control Center at 1-800-222-1222.

There are no available data on XEGLYZE use in pregnant women to evaluate for a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes.

The safety and effectiveness of XEGLYZE have been established in pediatric patients 6 months of age and older.
The safety and effectiveness of XEGLYZE have not been established in pediatric patients below the age of 6 months.
XEGLYZE is not recommended in pediatric patients under 6 months of age.

Store upright at room temperature, 20°C to 25°C (68°F to 77°F), with allowable excursions between 15°C and 30°C (59°F and 86°F).
Do not refrigerate or freeze.

Abametapir Resources
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