Alphabody

Alphabody is a type of protein engineering technology that is used to create small, stable, and versatile protein scaffolds. These scaffolds can be used for a variety of purposes, including the development of new therapeutics and diagnostics.

History

The Alphabody technology was developed by Complix, a biopharmaceutical company based in Belgium. The company was founded in 2008 and has been working on the development and commercialization of Alphabodies since then.

Structure and Function

Alphabodies are small, single-chain proteins that are composed of three alpha-helices. These helices are connected by short loop sequences, which give the Alphabody its unique structure. This structure is highly stable and resistant to denaturation, making it an ideal scaffold for protein engineering.

The function of an Alphabody can be tailored by modifying the amino acid sequence of the alpha-helices. This allows the Alphabody to bind to a specific target molecule with high affinity and specificity. Alphabodies can be designed to bind to a wide range of targets, including proteins, peptides, and nucleic acids.

Applications

Alphabodies have a wide range of potential applications in the field of biotechnology. They can be used to develop new therapeutics for the treatment of various diseases, including cancer, autoimmune diseases, and infectious diseases. They can also be used in diagnostics to detect the presence of specific molecules in a sample.

In addition to these applications, Alphabodies can also be used in basic research to study the function of proteins and other molecules. They can be used as tools to probe the structure and function of their target molecules, providing valuable insights into their roles in biological processes.

See Also

• Protein engineering
• Therapeutics
• Diagnostics
• Complix

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