BMS-493
BMS-493
BMS-493 is a synthetic compound that acts as a selective antagonist of the retinoic acid receptor (RAR). It is primarily used in scientific research to study the role of retinoic acid in various biological processes. Retinoic acid is a metabolite of vitamin A and plays a crucial role in cell differentiation, proliferation, and apoptosis.
Chemical Structure and Properties[edit | edit source]
BMS-493 is a small molecule with a complex chemical structure designed to specifically bind to the RARs, thereby inhibiting their activity. The chemical formula of BMS-493 is C₃₀H₃₄N₂O₃, and it has a molecular weight of 470.6 g/mol. The compound is characterized by its high affinity for RARs, making it a valuable tool in research settings.
Mechanism of Action[edit | edit source]
BMS-493 functions as an antagonist by binding to the ligand-binding domain of the retinoic acid receptors. This binding prevents the natural ligand, retinoic acid, from activating the receptor. As a result, the transcription of genes regulated by RARs is inhibited. This mechanism allows researchers to study the effects of retinoic acid signaling in various cellular contexts by observing the changes that occur when this pathway is blocked.
Applications in Research[edit | edit source]
BMS-493 is widely used in developmental biology and cancer research. In developmental biology, it helps elucidate the role of retinoic acid in embryonic development, particularly in the formation of the central nervous system and limb patterning. In cancer research, BMS-493 is used to study the potential of retinoic acid signaling pathways as therapeutic targets, given their involvement in cell growth and differentiation.
Safety and Handling[edit | edit source]
As with many research chemicals, BMS-493 should be handled with care. It is important to follow standard laboratory safety protocols, including the use of personal protective equipment such as gloves and goggles. The compound should be stored in a cool, dry place, away from light and moisture to maintain its stability.
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