Cilazaprilat

Cilazaprilat - the active metabolite of cilazapril, a pyridazine angiotensin converting enzyme (ace) inhibitor with antihypertensive activity. As a prodrug, cilazapril is rapidly metabolized in the liver to cilazaprilat; cilazaprilat competitively binds to and inhibits ace, thereby blocking the conversion of angiotensin I to angiotensin ii. This prevents the potent vasoconstrictive actions of angiotensin ii, resulting in vasodilation. Cilazaprilat also decreases angiotensin ii induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.

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Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on Cilazaprilat for any updates.

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