Cysteinyl leukotriene receptor 1
Cysteinyl leukotriene receptor 1 (CysLT1) is a protein that in humans is encoded by the CYSLTR1 gene. It is a member of the G protein-coupled receptor family and plays a crucial role in the function of the immune system.
Function[edit | edit source]
CysLT1 is a receptor for leukotrienes, which are lipid mediators involved in various human diseases including asthma and allergic rhinitis. The receptor is expressed in various human tissues, including the lung, spleen, and colon, and in specific white blood cells, such as eosinophils and macrophages.
Clinical significance[edit | edit source]
CysLT1 antagonists, such as montelukast and zafirlukast, are used in the treatment of asthma and allergic rhinitis. These drugs work by blocking the action of leukotrienes, thereby reducing inflammation and constriction of the airways.
Research[edit | edit source]
Research into the role of CysLT1 in other diseases, such as cardiovascular disease and cancer, is ongoing. Some studies suggest that CysLT1 may play a role in the progression of these diseases, although more research is needed to confirm these findings.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
