Diflucortolone valerate

Diflucortolone valerate is a corticosteroid used in dermatology to reduce inflammation and itching caused by certain skin conditions. It is a synthetic glucocorticoid and is marketed under various brand names worldwide.

Pharmacology

Diflucortolone valerate is a potent glucocorticoid that binds to the glucocorticoid receptor. This binding induces a response by modifying transcription and protein synthesis, influencing cellular proliferation and apoptosis, and stabilizing leukocyte cell membranes.

Uses

Diflucortolone valerate is used topically to treat a variety of skin conditions, including eczema, psoriasis, and contact dermatitis. It reduces the swelling, itching, and redness that can occur in these types of conditions.

Side Effects

Possible side effects of diflucortolone valerate include skin irritation, burning, itching, and dryness. These effects are usually mild and disappear after a few days of treatment. More serious side effects, such as skin thinning or discoloration, stretch marks, and hair growth changes, may occur with prolonged use or use of high potency corticosteroids.

Precautions

Before using diflucortolone valerate, patients should inform their healthcare provider if they have any allergies, if they have a history of poor blood circulation or immune system problems, or if they have had recent vaccinations.

See Also

• Corticosteroid
• Dermatology
• Eczema
• Psoriasis
• Contact dermatitis