Factor xiii deficiency

Factor XIII deficiency is a rare blood disorder characterized by abnormal blood clotting that can result in abnormal bleeding. Factor XIII is a protein that plays a crucial role in the clotting of blood. A deficiency of this factor can lead to a variety of symptoms, including nosebleeds, easy bruising, and delayed wound healing.

Symptoms[edit | edit source]

The symptoms of Factor XIII deficiency can vary greatly from person to person. Some people may experience only mild symptoms, while others may have severe bleeding problems. Common symptoms include:

Nosebleeds
Easy bruising
Delayed wound healing
Menorrhagia (heavy menstrual bleeding)
Hemarthrosis (bleeding into joint spaces)
Intracranial hemorrhage (bleeding into the brain)

Causes[edit | edit source]

Factor XIII deficiency is caused by mutations in the F13A1 or F13B gene. These genes provide instructions for making the two subunits of factor XIII. Mutations in either gene reduce the amount of factor XIII in the body, impairing the blood's ability to clot and leading to the symptoms of Factor XIII deficiency.

Diagnosis[edit | edit source]

Diagnosis of Factor XIII deficiency typically involves blood tests to measure the level of factor XIII in the body. A low level of factor XIII is indicative of the disorder. Genetic testing may also be performed to identify mutations in the F13A1 or F13B gene.

Treatment[edit | edit source]

Treatment for Factor XIII deficiency typically involves regular infusions of factor XIII concentrate to replace the missing or malfunctioning protein. This can help to prevent bleeding episodes and improve wound healing.

See also[edit | edit source]

Factor xiii deficiency Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.