Thrombotic microangiopathy

Thrombotic Microangiopathy (TMA) is a pathological process that results in thrombosis in capillaries and arterioles, due to an endothelial cell injury. It is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and organ dysfunction.

Causes[edit | edit source]

TMA can be caused by several factors, including genetic disorders, drugs, and infections. It can also be associated with malignancies, transplant rejection, and pregnancy.

Pathophysiology[edit | edit source]

The pathophysiology of TMA involves the damage to the endothelial cells lining the blood vessels. This damage can be caused by various factors, such as toxins, drugs, infections, and immune reactions. The damaged endothelial cells then expose the underlying tissue factor, which triggers the coagulation cascade and leads to the formation of thrombi.

Diagnosis[edit | edit source]

The diagnosis of TMA is based on the presence of microangiopathic hemolytic anemia, thrombocytopenia, and organ dysfunction. Additional tests may include blood tests, urinalysis, and imaging studies.

Treatment[edit | edit source]

The treatment of TMA depends on the underlying cause. It may include plasma exchange, immunosuppressive therapy, and supportive care. In severe cases, dialysis or transplantation may be required.

Prognosis[edit | edit source]

The prognosis of TMA varies depending on the underlying cause and the patient's response to treatment. In some cases, it can be life-threatening.

See also[edit | edit source]

Thrombotic microangiopathy Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.