Gwendalyn J. Randolph

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Gwendalyn J. Randolph is a prominent immunologist and biomedical scientist known for her significant contributions to the field of immunology and vascular biology. She is currently a professor at Washington University in St. Louis.

Early Life and Education

Randolph received her undergraduate degree in biology from Temple University. She then pursued her PhD in immunology at State University of New York Upstate Medical University. Her doctoral research focused on the role of monocytes and macrophages in inflammation.

Career

After completing her PhD, Randolph conducted postdoctoral research at The Rockefeller University in the laboratory of Ralph Steinman, a Nobel laureate known for his discovery of dendritic cells. During her postdoctoral work, she made significant discoveries about the trafficking of immune cells and their role in chronic inflammation.

Randolph joined the faculty at Mount Sinai School of Medicine in New York City, where she continued her research on monocyte and macrophage biology. In 2011, she moved to Washington University in St. Louis, where she is a professor in the Department of Pathology and Immunology.

Research Contributions

Randolph's research has significantly advanced the understanding of the immune system, particularly in the context of atherosclerosis, lymphatic system function, and inflammatory diseases. Her work has elucidated the mechanisms by which monocytes and macrophages contribute to the development and resolution of inflammation.

One of her notable contributions is the discovery of the role of the lymphatic system in the clearance of cholesterol from atherosclerotic plaques, which has implications for the treatment of cardiovascular diseases. She has also investigated the impact of obesity on the immune system and the development of metabolic syndrome.

Awards and Honors

Randolph has received numerous awards for her contributions to biomedical research, including the American Heart Association's Established Investigator Award and the National Institutes of Health's MERIT Award. She is also a fellow of the American Association for the Advancement of Science.

Personal Life

Randolph is married and has two children. She is an advocate for women in science and actively mentors young scientists in her laboratory.

Selected Publications

• Randolph, G.J., et al. "The role of the lymphatic system in cholesterol transport and atherosclerosis." Journal of Clinical Investigation.
• Randolph, G.J., et al. "Monocyte trafficking and chronic inflammation." Nature Reviews Immunology.

See Also

• Immunology
• Vascular biology
• Monocyte
• Macrophage
• Atherosclerosis
• Lymphatic system