ICI-185282
ICI-185,282 is a chemical compound that acts as a selective antagonist of the beta-adrenergic receptors. It is primarily used in research settings to study the physiological and pharmacological roles of beta-adrenergic receptors in various tissues.
Chemical Structure and Properties[edit | edit source]
ICI-185,282 is a synthetic compound with a complex chemical structure. It belongs to the class of compounds known as beta-blockers, which are characterized by their ability to block the action of endogenous catecholamines, such as epinephrine and norepinephrine, on beta-adrenergic receptors.
The molecular formula of ICI-185,282 is C18H28N2O3, and it has a molecular weight of approximately 320.43 g/mol. The compound is typically synthesized in a laboratory setting and is not used as a therapeutic agent in clinical practice.
Mechanism of Action[edit | edit source]
ICI-185,282 functions as a competitive antagonist at beta-adrenergic receptors. These receptors are part of the G protein-coupled receptor family and are involved in the regulation of cardiovascular, respiratory, and metabolic processes. By blocking these receptors, ICI-185,282 inhibits the physiological effects of catecholamines, leading to decreased heart rate, reduced cardiac output, and lowered blood pressure.
Research Applications[edit | edit source]
ICI-185,282 is primarily used in experimental research to investigate the role of beta-adrenergic receptors in various physiological and pathological conditions. It is often employed in studies involving:
- Cardiovascular research: To understand the effects of beta-blockade on heart function and blood pressure regulation.
- Metabolic studies: To explore the influence of beta-adrenergic receptors on metabolic rate and energy expenditure.
- Respiratory research: To examine the role of beta-adrenergic receptors in airway smooth muscle relaxation and bronchodilation.
Safety and Handling[edit | edit source]
As with many research chemicals, ICI-185,282 should be handled with care in a laboratory setting. Appropriate safety measures, including the use of personal protective equipment (PPE) such as gloves and goggles, should be employed to prevent exposure. The compound should be stored in a cool, dry place, away from direct sunlight and incompatible substances.
Also see[edit | edit source]
Template:Receptor pharmacology
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