KLF9

KLF9 (Krüppel-like factor 9) is a protein that in humans is encoded by the KLF9 gene. It is a member of the Krüppel-like factor family of transcription factors.

Function

KLF9 is a transcription factor that has been shown to regulate the epithelial differentiation of the uterus in mice. It is also involved in the regulation of neuronal differentiation and has been implicated in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

Structure

The KLF9 protein is composed of 244 amino acids and has a molecular weight of approximately 27 kDa. It contains three C2H2-type zinc fingers at the C-terminus, which are responsible for binding to specific DNA sequences.

Clinical significance

Alterations in the expression of KLF9 have been associated with several diseases. For example, decreased levels of KLF9 have been observed in the brains of patients with Alzheimer's disease and Parkinson's disease. In contrast, increased levels of KLF9 have been associated with the progression of endometrial cancer.

Research

Research on KLF9 is ongoing, with studies focusing on its role in neuronal differentiation and its potential as a therapeutic target for neurodegenerative diseases and cancer.

See also

• Krüppel-like factors
• Transcription factor
• Neurodegenerative diseases
• Endometrial cancer