Krukenberg tumor

Krukenberg tumor is a type of metastatic cancer that primarily originates from the stomach, but can also arise from other parts of the body such as the gallbladder, colon, breast, and lung. It is named after Friedrich Ernst Krukenberg, who first described it in 1896.

Epidemiology

Krukenberg tumors account for 1-2% of all ovarian tumors, and are most commonly found in women between the ages of 40 and 50. However, they can occur at any age.

Pathophysiology

The tumor is characterized by the presence of mucin-filled signet-ring cells in the ovary. These cells are typically derived from a primary adenocarcinoma located elsewhere in the body. The most common primary site is the stomach, followed by the colon, breast, and lung.

Clinical Presentation

Patients with a Krukenberg tumor often present with abdominal pain, bloating, ascites, and menstrual irregularities. In some cases, the tumor may be discovered incidentally during a routine pelvic examination or imaging study.

Diagnosis

The diagnosis of a Krukenberg tumor is typically made based on the histological examination of a biopsy specimen. Imaging studies such as ultrasound, computed tomography (CT) scan, and magnetic resonance imaging (MRI) can also be helpful in identifying the primary tumor and assessing the extent of disease.

Treatment

The treatment of a Krukenberg tumor depends on the location and stage of the primary tumor, as well as the patient's overall health status. Treatment options may include surgery, chemotherapy, radiation therapy, and targeted therapy.

Prognosis

The prognosis of a Krukenberg tumor is generally poor, with a median survival time of less than one year. Factors that may influence the prognosis include the stage of the primary tumor, the presence of other metastases, and the patient's overall health status.

See Also

• Ovarian cancer
• Metastatic cancer
• Stomach cancer
• Colon cancer
• Breast cancer
• Lung cancer

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