Malignant acrospiroma
Overview[edit | edit source]
Malignant acrospiroma, also known as malignant hidradenoma, is a rare type of skin cancer that originates from the sweat glands. It is considered a type of eccrine sweat gland tumor and is characterized by its aggressive behavior and potential to metastasize.
Pathophysiology[edit | edit source]
Malignant acrospiromas arise from the eccrine sweat glands, which are responsible for thermoregulation through the secretion of sweat. These tumors can occur anywhere on the body but are most commonly found on the head, neck, and extremities. The exact cause of malignant acrospiroma is not well understood, but it is believed to involve genetic mutations that lead to uncontrolled cell growth.
Clinical Presentation[edit | edit source]
Patients with malignant acrospiroma typically present with a solitary, firm, and sometimes painful nodule on the skin. The lesion may be skin-colored, erythematous, or bluish. Over time, the tumor can ulcerate and bleed. Due to its aggressive nature, malignant acrospiroma can invade surrounding tissues and metastasize to distant organs, including the lungs, liver, and lymph nodes.
Diagnosis[edit | edit source]
The diagnosis of malignant acrospiroma is primarily based on histological examination. A biopsy of the lesion is performed, and the tissue is examined under a microscope. Histologically, malignant acrospiromas show atypical cells with high mitotic activity and areas of necrosis. Immunohistochemical staining can aid in differentiating it from other skin tumors.
Treatment[edit | edit source]
The primary treatment for malignant acrospiroma is surgical excision with wide margins to ensure complete removal of the tumor. In cases where the tumor has metastasized, additional treatments such as radiation therapy or chemotherapy may be considered. Due to the rarity of the condition, there is no standardized treatment protocol, and management is often individualized.
Prognosis[edit | edit source]
The prognosis for patients with malignant acrospiroma varies depending on the stage at diagnosis and the presence of metastasis. Early detection and complete surgical excision can lead to a favorable outcome. However, once the tumor has metastasized, the prognosis becomes poor.
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Contributors: Prab R. Tumpati, MD
