Oxibendazole

Oxibendazole

Oxibendazole is an anthelmintic drug that is used primarily in the treatment of parasitic infections. It is a member of the benzimidazole class of anthelmintic drugs, which also includes albendazole and mebendazole. Oxibendazole is particularly effective against nematodes, but can also be used to treat other types of parasites.

History

Oxibendazole was first synthesized in the 1960s as part of a broader effort to develop new anthelmintic drugs. It was found to be particularly effective against nematodes, and has since become a standard treatment for these types of infections.

Pharmacology

Oxibendazole works by inhibiting the polymerization of tubulin, a protein that is essential for the formation of the cytoskeleton in cells. This disrupts the normal functioning of the cells, leading to their death. The drug is typically administered orally, and is absorbed rapidly from the gastrointestinal tract.

Clinical use

In humans, oxibendazole is used primarily to treat infections caused by nematodes, including ascariasis, hookworm infection, and trichuriasis. It is also used in veterinary medicine to treat a variety of parasitic infections in animals.

Side effects

Like all drugs, oxibendazole can cause side effects. The most common side effects are gastrointestinal symptoms, such as nausea and diarrhea. In rare cases, the drug can cause more serious side effects, such as liver damage or an allergic reaction.

See also

• Anthelmintic
• Benzimidazole
• Nematode