Oxidized-ATP
An encyclopedia article on Oxidized ATP
Oxidized ATP (oATP) is a modified form of adenosine triphosphate (ATP) where the purine ring has been oxidized. It is primarily used in research settings to study the role of ATP in cellular signaling, particularly in the context of purinergic receptors.
Structure and Properties[edit | edit source]
Oxidized ATP is structurally similar to ATP, with the primary difference being the oxidation of the purine ring. This modification alters its interaction with purinergic receptors, making it a useful tool for studying these pathways.
Biological Role[edit | edit source]
In biological systems, ATP serves as a key energy currency and signaling molecule. Oxidized ATP is not naturally occurring in significant amounts but is used experimentally to inhibit certain purinergic receptors, such as the P2X7 receptor. This inhibition can help elucidate the role of ATP in various physiological and pathological processes.
Research Applications[edit | edit source]
Oxidized ATP is widely used in research to:
- Inhibit P2X7 receptors: By blocking these receptors, researchers can study their role in inflammation, cell death, and immune responses.
- Investigate ATP signaling pathways: oATP helps in understanding how ATP functions as a signaling molecule in different tissues.
- Explore therapeutic potentials: By modulating purinergic signaling, oATP may have potential applications in treating diseases characterized by excessive inflammation or immune activation.
Mechanism of Action[edit | edit source]
Oxidized ATP acts as an antagonist to purinergic receptors, particularly the P2X7 receptor. This receptor is a ligand-gated ion channel that, when activated by ATP, can lead to the formation of a pore in the cell membrane, allowing ions and small molecules to pass through. By inhibiting this receptor, oATP can prevent the downstream effects of ATP signaling.
Safety and Handling[edit | edit source]
As with many chemical reagents used in research, oxidized ATP should be handled with care. Appropriate safety measures, including the use of personal protective equipment and working in a well-ventilated area, should be followed.
Also see[edit | edit source]
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Contributors: Prab R. Tumpati, MD
