S100A14
S100A14[edit | edit source]
S100A14 is a protein that belongs to the S100 family of calcium-binding proteins. It is encoded by the S100A14 gene, which is located on chromosome 1q21.3. S100A14 is primarily expressed in epithelial tissues and has been found to play a role in various cellular processes.
Structure[edit | edit source]
The S100A14 protein consists of 101 amino acids and has a molecular weight of approximately 11.5 kDa. It contains two calcium-binding EF-hand motifs, which are characteristic of the S100 protein family. These motifs allow S100A14 to bind calcium ions, which in turn regulate its function.
Function[edit | edit source]
S100A14 has been implicated in several cellular processes, including cell proliferation, differentiation, and apoptosis. It has also been shown to be involved in the regulation of cell migration and invasion. Studies have suggested that S100A14 may play a role in cancer progression and metastasis.
Clinical Significance[edit | edit source]
Aberrant expression of S100A14 has been observed in various types of cancer, including breast, lung, and ovarian cancer. High levels of S100A14 expression have been associated with poor prognosis and increased tumor aggressiveness. Therefore, S100A14 may serve as a potential biomarker for cancer diagnosis and prognosis.
Interactions[edit | edit source]
S100A14 has been found to interact with several other proteins, including p53, E-cadherin, and annexin A2. These interactions suggest that S100A14 may participate in complex signaling networks involved in cell adhesion, migration, and invasion.
References[edit | edit source]
1. S100 protein - Wikipedia article on the S100 protein family. 2. Chromosome 1 - Wikipedia article on chromosome 1. 3. Epithelial tissue - Wikipedia article on epithelial tissue. 4. Cell proliferation - Wikipedia article on cell proliferation. 5. Cell differentiation - Wikipedia article on cell differentiation. 6. Apoptosis - Wikipedia article on apoptosis. 7. Cell migration - Wikipedia article on cell migration. 8. Cancer progression - Wikipedia article on cancer progression. 9. Metastasis - Wikipedia article on metastasis. 10. Biomarker - Wikipedia article on biomarkers. 11. p53 - Wikipedia article on p53. 12. E-cadherin - Wikipedia article on E-cadherin. 13. Annexin A2 - Wikipedia article on annexin A2.
Categories[edit | edit source]
Templates[edit | edit source]
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Contributors: Prab R. Tumpati, MD
