TOP1

TNK2 (also known as ACK1) is a non-receptor tyrosine kinase that is encoded by the TNK2 gene in humans. This protein is involved in various cellular processes, including signal transduction, cell growth, and cytoskeletal reorganization.

Structure

TNK2 is a member of the ACK family of non-receptor tyrosine kinases. It contains several functional domains, including a tyrosine kinase domain, a SH3 domain, a Cdc42/Rac interactive binding (CRIB) domain, and a ubiquitin association (UBA) domain. These domains facilitate its interaction with other proteins and its role in signaling pathways.

Function

TNK2 plays a critical role in the regulation of cell signaling pathways. It is activated by binding to the small GTPase Cdc42, which leads to autophosphorylation and activation of its kinase activity. TNK2 is involved in the regulation of endocytosis, cell migration, and cell proliferation. It has been implicated in the signaling pathways of several growth factor receptors, including the epidermal growth factor receptor (EGFR).

Clinical Significance

Aberrant expression or mutation of TNK2 has been associated with various types of cancer, including breast cancer, prostate cancer, and lung cancer. Overexpression of TNK2 can lead to increased cell proliferation and survival, contributing to tumorigenesis. As a result, TNK2 is considered a potential target for cancer therapy.

Research and Therapeutic Potential

Research is ongoing to develop inhibitors of TNK2 as potential therapeutic agents for cancer treatment. Several small molecule inhibitors have been identified that can selectively inhibit TNK2 activity, showing promise in preclinical studies.

Also see

• Tyrosine kinase
• Signal transduction
• Cdc42
• Epidermal growth factor receptor
• Cancer therapy