TTNPB
Overview[edit | edit source]
TTNPB (also known as Arotinoid acid) is a synthetic retinoid, which is a derivative of Vitamin A. It is primarily used in research settings to study its effects on cellular differentiation, proliferation, and apoptosis. TTNPB is known for its potent activity in modulating retinoic acid receptors (RARs), which are crucial in regulating gene expression during embryonic development and in maintaining epithelial tissues.
Chemical Structure and Properties[edit | edit source]
TTNPB is chemically classified as a retinoid, with the IUPAC name 4-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid. Its molecular formula is C24H28O2, and it has a molecular weight of 348.48 g/mol. The compound is characterized by its rigid structure, which contributes to its high affinity for retinoic acid receptors.
Mechanism of Action[edit | edit source]
TTNPB exerts its biological effects by binding to and activating retinoic acid receptors (RARs), which are nuclear receptors that regulate gene expression. Upon binding to RARs, TTNPB influences the transcription of genes involved in cell differentiation, growth, and apoptosis. This makes it a valuable tool in studying developmental biology and cancer research.
Applications in Research[edit | edit source]
TTNPB is widely used in laboratory research to:
- Investigate the role of retinoic acid signaling in embryonic development.
- Study the effects of retinoids on skin differentiation and keratinization.
- Explore potential therapeutic applications in cancer treatment, particularly in acute promyelocytic leukemia (APL).
Safety and Handling[edit | edit source]
As with many synthetic retinoids, TTNPB should be handled with care in a laboratory setting. It is important to use appropriate personal protective equipment (PPE) and follow safety protocols to avoid exposure. TTNPB can be toxic if ingested or absorbed through the skin, and it may cause irritation to the eyes and respiratory tract.
Also see[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
- [PubChem entry for TTNPB](https://pubchem.ncbi.nlm.nih.gov/compound/TTNPB)
- [Research articles on TTNPB](https://www.ncbi.nlm.nih.gov/pubmed/?term=TTNPB)
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Contributors: Prab R. Tumpati, MD
