Abametapir

What abametapir?

Abametapir (Xeglyze) is a prescription medicine used to get rid of head lice in people 6 months of age and older.

What are the uses of this medicine?

• This medicine is indicated for the topical treatment of head lice infestation in patients 6 months of age and older.
• This medicine should be used in the context of an overall lice management program:
• Wash (with hot water) or dry-clean all recently worn clothing, hats, used bedding and towels
• Wash personal care items such as combs, brushes, and hair clips in hot water
• Use a fine-tooth comb or special nit comb to remove dead lice and nits

How does this medicine work?

• Abametapir (5,5’-dimethyl 2,2’-bipyridinyl) is a metalloproteinase inhibitor.
• Metalloproteinases have a role in physiological processes critical to egg development and survival of lice.

Who Should Not Use this medicine ?

• Use is not recommended in pediatric patients under 6 months of age because of the potential for increased systemic absorption.

Is this medicine FDA approved?

• It was approved for use in the United States in 2020.

How should this medicine be used?

• For topical use only.
• Not for oral, ophthalmic, or intravaginal use.
• Shake well before use.
• Apply XEGLYZE to dry hair in an amount sufficient (up to the full content of one bottle) to thoroughly coat the hair and scalp.
• Avoid contact with eyes.
• Massage XEGLYZE into the scalp and throughout the hair; leave on the hair and scalp for 10 minutes and then rinse off with warm water.
• Treatment with XEGLYZE involves a single application.
• Discard any unused product.
• Do not flush contents down sink or toilet.

What are the dosage forms and brand names of this medicine?

This medicine is available in fallowing doasage form:

• As lotion Lotion, 0.74% [weight by weight]

This medicine is available in fallowing brand namesː

• XEGLYZE

What side effects can this medication cause?

Common possible side effects of this medicine include:

• erythema
• rash
• skin burning sensation
• contact dermatitis
• vomiting
• eye irritation
• pruritus
• hair color changes

What special precautions should I follow?

• Administer only under direct supervision of an adult.
• systemic exposure to benzyl alcohol has been associated with serious adverse reactions and death in neonates and low birth-weight infants.
• Safety and effectiveness in pediatric patients below the age of 6 months have not been established.

What to do in case of emergency/overdose?

• Ingestion of benzyl alcohol in large quantities may result in gastrointestinal (nausea, vomiting, diarrhea) and central nervous system (headache, ataxia, convulsions, coma) adverse reactions.
• Serious adverse reactions may include respiratory depression and death.
• If accidentally swallowed, advise the patient or the caregiver to call their Poison Control Center at 1-800-222-1222.

Can this medicine be used in pregnancy?

• There are no available data on XEGLYZE use in pregnant women to evaluate for a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes.

Can this medicine be used in children?

• The safety and effectiveness of XEGLYZE have been established in pediatric patients 6 months of age and older.
• The safety and effectiveness of XEGLYZE have not been established in pediatric patients below the age of 6 months.
• XEGLYZE is not recommended in pediatric patients under 6 months of age.

What should I know about storage and disposal of this medication?

• Store upright at room temperature, 20°C to 25°C (68°F to 77°F), with allowable excursions between 15°C and 30°C (59°F and 86°F).
• Do not refrigerate or freeze.

• Dailymed label info on Abametapir
• FDA Abametapir

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