Alpha-3 beta-4 nicotinic receptor
Alpha-3 beta-4 nicotinic receptor[edit | edit source]
The Alpha-3 beta-4 nicotinic receptor is a type of nicotinic acetylcholine receptor (nAChR) that is primarily found in the autonomic nervous system. It is a ligand-gated ion channel that is activated by the neurotransmitter acetylcholine as well as by nicotine.
Structure[edit | edit source]
The Alpha-3 beta-4 nicotinic receptor is a pentameric complex composed of five subunits. The most common configuration includes three alpha-3 subunits and two beta-4 subunits. Each subunit spans the cell membrane and contributes to the formation of a central ion channel. The receptor is permeable to cations, primarily sodium (Na+) and calcium (Ca2+), which flow into the cell upon activation.
Function[edit | edit source]
This receptor plays a crucial role in the transmission of signals in the autonomic nervous system. It is involved in the modulation of neurotransmitter release and is essential for the proper functioning of the sympathetic nervous system. Activation of the Alpha-3 beta-4 nicotinic receptor leads to depolarization of the post-synaptic membrane, which can result in various physiological responses such as increased heart rate and blood pressure.
Clinical Significance[edit | edit source]
The Alpha-3 beta-4 nicotinic receptor has been implicated in several disorders. Dysregulation of this receptor is associated with autonomic dysfunction and has been studied in the context of hypertension, addiction, and neuropathic pain. It is also a target for certain pharmacological agents that aim to modulate autonomic responses.
Research[edit | edit source]
Ongoing research is focused on understanding the precise role of the Alpha-3 beta-4 nicotinic receptor in health and disease. Studies are exploring its potential as a therapeutic target for conditions such as nicotine addiction and chronic pain.
Also see[edit | edit source]
- Nicotinic acetylcholine receptor
- Autonomic nervous system
- Acetylcholine
- Sympathetic nervous system
- Ion channel
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