Anti-NMDA receptor encephalitis

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Obesity, Sleep & Internal medicine
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Anti-NMDA receptor encephalitis
File:NR1-NR2B subunit.png
Synonyms	N/A
Pronounce	N/A
Specialty	N/A
Symptoms	Psychosis, Seizures, Memory loss, Autonomic dysfunction, Movement disorders
Complications	N/A
Onset	Typically young adults, more common in females
Duration	Weeks to months
Types	N/A
Causes	Autoimmune reaction against NMDA receptors
Risks	Ovarian teratoma, other tumors, viral infections
Diagnosis	Cerebrospinal fluid analysis, EEG, MRI, detection of anti-NMDA receptor antibodies
Differential diagnosis	Infectious encephalitis, Other autoimmune encephalitis, Psychiatric disorders
Prevention	N/A
Treatment	Immunotherapy, Corticosteroids, Plasmapheresis, Intravenous immunoglobulin, Tumor removal
Medication	N/A
Prognosis	Generally good with treatment, but can be severe or fatal if untreated
Frequency	Rare
Deaths	N/A

Anti-NMDA receptor encephalitis is an autoimmune neurological disorder characterized by inflammation of the brain (encephalitis) that results from the production of antibodies against NMDA (N-methyl-D-aspartate) receptors, which are critical for memory function and cognition.

File:Extreme delta brush in anti-NMDAr encephalitis.png

Extreme delta brush in anti-NMDAr encephalitis

Pathophysiology

The disease process involves the generation of autoantibodies that target NMDA receptors in the brain. These antibodies disrupt normal neurological processes by altering the functioning of these receptors, leading to the array of neurological and psychiatric symptoms seen in the condition.

Clinical Presentation

The onset of Anti-NMDA receptor encephalitis is usually subtle, beginning with non-specific symptoms such as fever, headache, and fatigue. As the disease progresses, patients often exhibit psychiatric symptoms, which may include delusions, hallucinations, and agitation. Cognitive impairment and confusion are also common. Over time, the disease may lead to severe neurological issues such as seizures. Autonomic instability can also occur, leading to fluctuations in heart rate, blood pressure, and respiratory rate. This disorder may progress rapidly and may lead to respiratory failure, requiring mechanical ventilation in severe cases.

Diagnosis and Treatment

Diagnosis involves the detection of anti-NMDA receptor antibodies in the cerebrospinal fluid (CSF). Brain imaging and electroencephalography (EEG) may also be utilized to exclude other potential causes of encephalitis. Treatment involves the removal of antibodies, often through immunosuppressive therapies, plasmapheresis, or intravenous immunoglobulin (IVIG). Early detection and treatment of the condition can significantly improve prognosis.

See Also

• NMDA receptor
• Encephalitis
• Autoimmune diseases